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REC reference: 21/EE/0116

ISRCTN: 91141124

Clinical Trials Unit: Clinical Nottingham Trials Unit

Sponsor: University College London

Funder: National Institutes for Health Research (NIHR)

Recruitment Target: 480

Overall Trial End Date: [To Be added]

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This study/project is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project reference NIHR128757). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.